Which is better, Rejuran or Profhilo?

Neither is better in the abstract — they treat different things. Profhilo suits dehydration and early laxity; Rejuran suits texture, elasticity and thin skin. The right choice depends on your primary concern, established at assessment.

Can I have Rejuran and Profhilo together?

Yes, and a sequenced plan using both suits some patients. They are usually spaced rather than done on the same day, so each can be assessed on its own merits and you know which treatment produced which effect.

Which one lasts longer?

Both are typically maintained at six to twelve month intervals after a completed course. Duration varies more by individual skin, lifestyle and sun exposure than by which of the two treatments you choose.

Which has less downtime?

They are broadly similar. Both leave small injection-point bumps that settle within 24–48 hours, with possible redness and bruising. Neither is a treatment to have two days before an important event.

Which needs fewer sessions?

Profhilo, typically two sessions four weeks apart, compared with three to four for Rejuran. If completing a course quickly matters to you, that is a genuine practical difference.

Is Profhilo a filler?

No. It uses hyaluronic acid, the same base ingredient as many fillers, but it is formulated to spread and hydrate rather than to hold shape. It does not add volume or change contour.

Which is better for under-eye skin?

Rejuran Eye is formulated specifically for the thin periorbital skin. Profhilo is not typically used in that area. Neither treats hollowing or pigmentation, which have different causes and different solutions.

Can either treatment tighten sagging skin?

Neither lifts significant sagging. Both can improve early laxity by improving skin quality, but where there is genuine tissue descent and excess skin, no injectable repositions it and surgery is the honest answer.

Which is more expensive?

Compare course cost rather than session cost, since the two require different numbers of sessions. Current published per-session and course prices for both are on the prices page.

Can I have either while pregnant?

No. Neither is used during pregnancy or breastfeeding, as safety has not been established in these groups. Treatment should be postponed until afterwards.

Skin Health

Rejuran vs Profhilo: Which Treatment Suits Your Skin?

They are both injected, neither is a filler, and they solve different problems. A side-by-side comparison of mechanism, course, downtime and who each one suits.

Dr. Maliha Dar· DHA-Licensed GP4 October 20266 min read

Medically reviewed by Dr. Maliha Dar, DHA-licensed General Practitioner (licence 29664582-005) · 29 September 2026

Header image: AI-generated illustration; not a real patient.

In short

Both are injectables that improve skin quality rather than adding volume, but they work differently. Profhilo is bio-remodelling hyaluronic acid targeting hydration and early laxity over two sessions. Rejuran is a polynucleotide treatment targeting texture, elasticity and repair over three to four sessions.

Key facts

Both are	Skin-quality injectables, not fillers
Profhilo is	Bio-remodelling hyaluronic acid
Rejuran is	Polynucleotides from purified salmon DNA
Profhilo course	Usually 2 sessions, 4 weeks apart
Rejuran course	Usually 3–4 sessions, 2–4 weeks apart
Can they be combined?	Often yes, sequenced rather than same-day
Neither will	Lift sagging skin or replace lost volume

This is one of the most common questions asked in consultation, and the honest answer is that it depends on which problem you actually have. They are not competing versions of the same treatment.

Both are injected into the skin, neither adds volume, and both improve how skin looks and behaves. Beyond that they differ in mechanism, in the course required, and in the concern they address best.

Side-by-side comparison

The table below sets out the practical differences. Which matters most to you depends on your primary concern.

Typical protocols. Your plan is confirmed after an individual skin assessment.
	Profhilo	Rejuran
Active ingredient	Stabilised hyaluronic acid	Polynucleotides (salmon-derived)
Mechanism	Slow-release HA; hydration and bio-remodelling	Supports fibroblast activity and tissue repair
Best for	Dehydration, crepey skin, early laxity	Texture, elasticity, resilience, thin skin
Typical course	2 sessions, 4 weeks apart	3–4 sessions, 2–4 weeks apart
Session length	30–45 minutes	45–60 minutes
Downtime	Small bumps 24–48 hours	Bumps and redness 1–2 days
When results show	Hydration in days; firmness over 4–8 weeks	Builds over 3–4 weeks per session
Maintenance	Every 6 months typically	Every 6–12 months typically
Not suitable if	Pregnancy, breastfeeding, active infection	Fish allergy, pregnancy, breastfeeding

Timeline comparing a two-session Profhilo course with a three-to-four-session Rejuran course

How to choose between them

A reasonable rule of thumb, though it is not a substitute for assessment:

Skin feels tight, looks dull and dehydrated, with early looseness — Profhilo is usually the better starting point, and the two-session protocol is quicker to complete.
Skin texture is rough or uneven, with fine crepey lines and thin skin — Rejuran is generally the better fit.
The concern is specifically the under-eye area — Rejuran Eye is formulated for that skin; Profhilo is not typically used there.
You want the shortest course — Profhilo, at two sessions rather than three or four.
You have a fish or seafood allergy — Rejuran is not an option; Profhilo may be.

Chart matching five common skin concerns to Profhilo or Rejuran as a starting point

Can you have both?

Yes, and for some patients a sequenced plan using both is more sensible than choosing one. They act on different aspects of skin quality, so the effects are complementary rather than duplicated.

They are not usually performed on the same day. Spacing them allows each to be assessed on its own, which matters — if everything is done at once and the result is good, you have no idea which treatment delivered it, and you pay for both again next time.

A typical sequenced approach completes one course first, assesses at the end of it, then introduces the second if the remaining concern justifies it. This also spreads the cost, which is worth saying plainly.

What neither treatment will do

Both are skin-quality treatments. Neither repositions tissue.

If the concern is an established jowl, hanging skin along the jaw or significant neck laxity, neither of these will lift it, and adding product to a lax face can make heaviness more obvious rather than less. Surgery is the treatment that addresses genuine descent, and a practitioner who tells you so is being straight with you. Our guide to skin laxity covers where the non-surgical limit sits.

Equally, neither replaces lost volume. If cheeks have flattened and folds have deepened because the support beneath has gone, that is a volume problem and needs a different category of treatment.

Cost and practical planning

Both are priced per session, and because both require a course, the meaningful figure is the course cost rather than the single-session price. Current published rates for both are on the prices page, including course pricing where it applies.

Plan around downtime for either. Small injection bumps are normal for a day or two, so avoid booking immediately before an event.

A clinician examining a woman's skin texture through a magnifying lamp during a consultation — AI-generated illustration; not a real patient.

If you are not sure which category your concern falls into, that is precisely what a consultation is for. Book an assessment with Dr. Maliha Dar, or read our fuller guide to Rejuran and Profhilo.

Frequently asked questions

Which is better, Rejuran or Profhilo?: Neither is better in the abstract — they treat different things. Profhilo suits dehydration and early laxity; Rejuran suits texture, elasticity and thin skin. The right choice depends on your primary concern, established at assessment.
Can I have Rejuran and Profhilo together?: Yes, and a sequenced plan using both suits some patients. They are usually spaced rather than done on the same day, so each can be assessed on its own merits and you know which treatment produced which effect.
Which one lasts longer?: Both are typically maintained at six to twelve month intervals after a completed course. Duration varies more by individual skin, lifestyle and sun exposure than by which of the two treatments you choose.
Which has less downtime?: They are broadly similar. Both leave small injection-point bumps that settle within 24–48 hours, with possible redness and bruising. Neither is a treatment to have two days before an important event.
Which needs fewer sessions?: Profhilo, typically two sessions four weeks apart, compared with three to four for Rejuran. If completing a course quickly matters to you, that is a genuine practical difference.
Is Profhilo a filler?: No. It uses hyaluronic acid, the same base ingredient as many fillers, but it is formulated to spread and hydrate rather than to hold shape. It does not add volume or change contour.
Which is better for under-eye skin?: Rejuran Eye is formulated specifically for the thin periorbital skin. Profhilo is not typically used in that area. Neither treats hollowing or pigmentation, which have different causes and different solutions.
Can either treatment tighten sagging skin?: Neither lifts significant sagging. Both can improve early laxity by improving skin quality, but where there is genuine tissue descent and excess skin, no injectable repositions it and surgery is the honest answer.
Which is more expensive?: Compare course cost rather than session cost, since the two require different numbers of sessions. Current published per-session and course prices for both are on the prices page.
Can I have either while pregnant?: No. Neither is used during pregnancy or breastfeeding, as safety has not been established in these groups. Treatment should be postponed until afterwards.

References

[1]Journal of Cosmetic Dermatology. Polydeoxyribonucleotide in aesthetic and regenerative dermatology: a review of mechanisms and clinical applications (2023).
[2]Clinical, Cosmetic and Investigational Dermatology. Stabilised hyaluronic acid for skin bio-remodelling: mechanism and clinical outcomes (2021).

This article was last updated on 29 September 2026. Clinical content is reviewed at least every 12 months, and sooner if guidance changes.

Medical Disclaimer

This article is for educational purposes only and does not replace a personalised medical consultation. Treatment suitability varies by individual. Please book a consultation with Dr. Maliha Dar before proceeding with any aesthetic procedure.

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